Allogenic Stem Cell Transplantation and Total Body Irradiation
نویسنده
چکیده
The clinical importance of bone marrow transplantation has increased considerably in recent decades. More than 450 centers for bone marrow transplantation now exist worldwide, performing more than 5000 transplantations per year. The number of transplant centers and patients has increased dramatically in Turkey in the last several years. When transplant donor and recipient are different individuals, hematopoietic graft is known as allogeneic graft. Total body irradiation (TBI) remains an important component of allogeneic hematopoietic stem cell transplant, with the goal of eradicating residual malignant cells and modulating the immune system of the transplant recipient. TBI is especially advantageous in allogeneic stem cell transplantation, since its biological effects can be exerted uniformly without sparing the “sanctuary” sites, such as nervous system or testicles. In this report, the role of TBI in allogeneic stem cell transplantation is reviewed.
منابع مشابه
Busulfan and total body irradiation as antihematopoietic stem cell agents in the preparation of patients with congenital bone marrow disorders for allogenic bone marrow transplantation.
The capacity of busulfan and total body irradiation to ablate hematopoietic stem cells as preparation for the allogeneic bone marrow transplantation of patients with congenital bone marrow disorders was studied. Fourteen patients received 18 transplants; busulfan was used in the preparatory regimen of eight transplants and total body irradiation in the regimens of six transplants. Sustained hem...
متن کاملPediatric Hematopoietic Stem Cell Transplantation
The introduction and evolution of hematopoietic stem cell transplantation (HSCT) could be traced back to 1950s, to the studies on interactions among irradiation, covering spleen and bone marrow from it and injection of bone marrow cells. Today, HSCT is considered a well-established, effective and promising means of therapy for various malignant and non-malignant medical conditions, both in chil...
متن کاملSyngeneic and allogeneic bone marrow engraftment after total body irradiation: dependence on dose, dose rate, and fractionation.
Murine bone marrow chimera models were used to assess the efficacy of host total body irradiation (TBI) given at different doses, dose rates, and fractionation schemes in providing for engraftment of syngeneic and allogeneic bone marrow. B6-Hbbd congenic and LP mice, respectively, were used as donors (10(7) bone marrow cells) for syngeneic and allogenic (H-2 compatible) transplantation in stand...
متن کاملallogenic bone marrow transplantation in the preparation of patients with congenital bone marrow disorders for Busulfan and total body irradiation as antihematopoietic stem cell agents
http://bloodjournal.hematologylibrary.org/site/misc/rights.xhtml#repub_requests Information about reproducing this article in parts or in its entirety may be found online at: http://bloodjournal.hematologylibrary.org/site/misc/rights.xhtml#reprints Information about ordering reprints may be found online at: http://bloodjournal.hematologylibrary.org/site/subscriptions/index.xhtml Information abo...
متن کاملComparison of Functional Competence of Umbilical Cord and Adult Peripheral Blood Dendritic Cells in Allogenic Mixed Leukocyte Reaction
Background: Dendritic cells (DCs) are the most potent stimulators of primary T cell responses and play a key role in immune reactions after stem cell transplantation. Very little is known about the cord blood (CB) dendritic cells and their potential involvement in the low incidence and lower severity of acute graft-versus-host disease after CB transplantation. Objectives: The aim of this stud...
متن کامل